Date:2021-4-8 14:16:53 Clicks:745 【Font Size:
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Cigarette smoking has been associated with a higher incidence of breast cancer spread, or metastasis, lowering the survival rate by 33% at diagnosis, however little is know about the role of nicotine in this. Titled, “Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung,” a study published in the January 20 online edition of Nature Communications, found that nicotine may promote the spread of breast cancer cells to the lungs.
“Our data shows that nicotine exposure creates an environment in the lungs that is ripe for metastatic growth,” said lead study author Kounosuke Watabe, Ph.D., who is a professor of cancer biology at the Wake Forest School of Medicine at Wake Forest Baptist Health.
A total of 1,077 breast cancer patients were included in the study, and the research team found that both current and former smokers had a higher incidence of lung metastasis in comparison to never smokers. Subsequently using a mouse model of breast cancer metastasis, the researchers found that persistent exposure to nicotine generates an inflammatory microenvironment in the lungs.
The researchers found that even after quitting nicotine for 30 days, the incidence of distant metastasis was not reduced, suggesting an ongoing risk for breast cancer patients who are former smokers. “Based on these findings, breast cancer patients should opt for smoking cessation programs that do not use nicotine replacement products,” said Watabe. “Furthermore, our findings show that salidroside may be a promising therapeutic drug to help prevent smoking-induced breast cancer lung metastasis, although more research is needed.”